Bovine Viral Diarrhea Virus: Prevention of Persistent Fetal Infection by a Combination of Two Mutations Affecting E RNase and N Protease
نویسندگان
چکیده
Bovine Viral Diarrhea Virus: Prevention of Persistent Fetal Infection by a Combination of Two Mutations Affecting E RNase and N Protease Gregor Meyers,* Andreas Ege, Christiane Fetzer,† Martina von Freyburg,‡ Knut Elbers, Veronica Carr, Helen Prentice, Bryan Charleston, and Eva-Maria Schürmann Institut für Immunologie, Friedrich-Loeffler-Institut, D-72001 Tübingen, Germany; Boehringer Ingelheim Vetmedica GmbH, D-55216 Ingelheim am Rhein, Germany; and Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
منابع مشابه
Bovine viral diarrhea virus: prevention of persistent fetal infection by a combination of two mutations affecting Erns RNase and Npro protease.
Different genetically engineered mutants of bovine viral diarrhea virus (BVDV) were analyzed for the ability to establish infection in the fetuses of pregnant heifers. The virus mutants exhibited either a deletion of the overwhelming part of the genomic region coding for the N-terminal protease N(pro), a deletion of codon 349, which abrogates the RNase activity of the structural glycoprotein E(...
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